Epidemiological updates of venous thromboembolism in a Chinese population

published_or_final_versio

Effectiveness of proximal intra-operative salvage Palmaz stent placement for endoleak during endovascular aneurysm repair

published_or_final_versio

Angioplasty of forearm arteries as a finger salvage procedure for patient with end-stage renal failure

Case Reportpublished_or_final_versio

Infectious anastomotic pseudoaneurysm complicating renal allograft: case report and review of literature

published_or_final_versio

Successful treatment of jellyfish sting-induced severe digital ischemia with intravenous iloprost infusion

published_or_final_versio

Epidemiological updates of venous thromboembolism in a Chinese population

Abstract and Free Paper Presentationpostprin

Effectiveness and durability of open versus endovascular repair of abdominal aortic aneurysm in octogenarians

Speakers' corner: Clinical trial updates and selected original research abstracts – EVARpublished_or_final_versio

Cloning and expression analysis of two distinct HIF-alpha isoforms – gcHIF-1alpha and gcHIF-4alpha – from the hypoxia-tolerant grass carp, Ctenopharyngodon idellus

BACKGROUND: Hypoxia-inducible factors (HIFs) are involved in adaptive and survival responses to hypoxic stress in mammals. In fish, very little is known about the functions of HIFs. RESULTS: We have cloned and characterized two distinct HIF-alpha cDNAs – gcHIF-1alpha and gcHIF-4alpha – from the hypoxia-tolerant grass carp. The deduced gcHIF-1alpha protein is highly similar to the HIF-1alphas (57–68%) from various vertebrate species, while gcHIF-4alpha is a novel isoform, and shows an equivalent degree of amino acid identity (41–47%) to the HIF-1alpha, HIF-2alpha and HIF-3alpha proteins so far described. Parsimony analysis indicated that gcHIF-4alpha is most closely related to the HIF-3alpha proteins. Northern blot analysis showed that mRNA levels of gcHIF-1alpha and gcHIF-4alpha differ substantially under normoxic and hypoxic conditions, while Western blot studies demonstrated that the endogenous protein levels for both gcHIF-1alpha and gcHIF-4alpha are similarly responsive to hypoxia. Our findings suggest that both gcHIF-1alpha and gcHIF-4alpha are differentially regulated at the transcriptional and translational levels. HRE-luciferase reporter assays show that both proteins function as transcription activators and play distinct roles in modulating the hypoxic response in grass carp. CONCLUSION: There are at least two distinct HIF-alpha isoforms – gcHIF-1alpha and gcHIF-4alpha – in the hypoxia-tolerant grass carp, which are differentially expressed and regulated in different fish organs in response to hypoxic stress. Overall, the results suggest that unique molecular mechanisms operate through these two HIF-alpha isoforms, which underpin the hypoxic response in the hypoxia-tolerant grass carp

Predictors common to cardiovascular and cancer outcomes in a population-based 13-year prospective study in Hong Kong

Oral PresentationINTRODUCTION: Cardiovascular diseases (CVD) and cancer are the two leading causes of death in Hong Kong. Obesity is becoming increasingly prevalent in the local population and has been reported to be associated with CVD and some forms of cancer in the western world. In this study, we attempted to identify the aetiological factors linking obesity to both CVD and cancer among Hong Kong Chinese. METHODS: Subjects were recruited from the Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS) …published_or_final_versionThe 16th Medical Research Conference, The University of Hong Kong, Hong Kong, 22 January 2011. In Hong Kong Medical Journal, 2011, v. 17 suppl. 1, p. 56, abstract no. 9

Serum adiponectin in relation to other obesity-related biomarkers in predicting type 2 diabetes: a 5-year prospective study

Oral PresentationAIMS: To identify obesity-related serum biomarkers associated with the development of type 2 diabetes in a Chinese population and to examine if these biomarkers added values to conventional risk factors in diabetes prediction. METHODS: We studied 1315 non-diabetic subjects from the prospective Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS). Serum biomarkers including adiponectin, tumour necrosis …published_or_final_versionThe 17th Medical Research Conference, The University of Hong Kong, Hong Kong, 14 January 2012. In Hong Kong Medical Journal, 2012, v. 18 suppl. 1, p. 57, abstract no. 8